Up at 5AM: The 5AM Solutions Blog

Here's Why Serious People Care About Lil Bub’s Genome

Posted on Tue, Jun 02, 2015 @ 03:00 PM

Lil Bub is the internet’s favorite feline. With her perpetually kitten-like features, short legs, and snubbed nose, she’s irresistible. Even to science.

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Tags: personalized medicine, genome, cat genome

Genes, Drugs, and Diagnostics: How Clinical Trials Work

Posted on Wed, May 27, 2015 @ 11:25 AM

In my last Map of Biomedicine blog post, I talked about the different phases of clinical trials and a little bit about how trials are structured. I mentioned that trial is really just an experiment designed to test a hypothesis. When you studied science in school you learned about the scientific method:

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Tags: clinical trials, personalized medicine, map of biomedicine, genes, drugs

New Studies Could Lead to New Diagnostics for Alzheimer's Disease

Posted on Thu, May 21, 2015 @ 03:30 PM

Two new studies published in JAMA this week confirm that amyloid plaques on the brain predict future Alzheimer's Disease (AD). What's more, there is evidence that the plaques appear decades before patients experience the cognitive declines associated with AD. Researchers have long suspected that amyloid plaques precede the disease, but according to an article in the New York Times, this new research is "[t]he largest analysis to date of amyloid plaques in people’s brains [and it] confirms that the presence of the substance can help predict who will develop Alzheimer’s and determine who has the disease."

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Tags: research, clinical trials, map of biomedicine, diagnostics, Alzheimer's Disease

New Standard Moves NGS Closer to Clinical Practice

Posted on Tue, May 19, 2015 @ 03:00 PM

Last week, the National Institute of Standards and Technology (NIST,) working through the  Genome in a Bottle Consortium (GIABC) (a NIST-funded and initiated working group) pushed next generation sequencing (NGS) a little closer to being adopted into regular clinical practice. NIST/GIABC have released a standard for measuring the accuracy of genetic tests. 

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Tags: personalized medicine, map of biomedicine, genetic testing, NGS Sequencing

Put Away Your Winter Genes

Posted on Thu, May 14, 2015 @ 02:30 PM

The azaleas are in full, colorful blossom in my suburban Washington, DC neighborhood. To me their appearance signals spring marching toward summer; the end of the last of winter's blahs. According to a paper published in Nature Communications last Tuesday, the impact of seasonal changes on human health are much deeper than aesthetic, and in, fact, may be genetic.

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Tags: research, personalized medicine, genes

Getting Drugs to (More) Patients - Global Edition

Posted on Tue, May 12, 2015 @ 04:30 PM

The newest installments in the Map of Biomedicine blog posts take us down the routes that get drugs to patients, primarily in the United States. Of course, we are all patients at one time or other regardless of where we live. Without a doubt, the route to getting effective therapies from the lab to your local pharmacist is convoluted and expensive even if you live in a wealthy nation. If you don't, making the most effective treatments available to the people who need them most in middle- and low-income nations is more difficult.   

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Tags: map of biomedicine, drug development, drugs, World Health Oranization

Clinical Trial Basics on the Map of Biomedicine

Posted on Thu, May 07, 2015 @ 02:00 PM

As I said in my last post, one of the key components of the Map of Biomedicine is how new treatments get developed. That’s one of the parts of the map that is highlighted, as shown below.

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Tags: clinical trials, biomedicine, map of biomedicine, drug development, Vignette 2

Can We Find a Balance Between Privacy and Meaningful Use?

Posted on Tue, May 05, 2015 @ 04:01 PM

You’ve probably noticed that there is a lot of conversation about meaningful use lately. It’s not a new concept in health IT, but these days, it’s timely.

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Tags: meaningful use, EHR, interoperability

WHO reminds us that there’s still an immunization gap

Posted on Thu, Apr 30, 2015 @ 06:15 PM

The World Health Organization’s (WHO) wrapped up its annual World Immunization Week. The WHO kicked off the once-yearly effort to re-ignite the world’s public health agencies’ commitment to ensuring that their constituents’ are immunized against vaccine-preventable illnesses on Monday. 

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Tags: vaccines, vaccinations, immunization, World Health Oranization

Science Shows Well in Time's "100" List But Something's Missing

Posted on Tue, Apr 28, 2015 @ 04:24 PM

On Sunday, I had a chance to thumb through Time’s “100 Most Influential People in the World” issue. The list is broken into 5 categories: Titans, Pioneers, Artists, Leaders, and Icons. 

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Tags: life sciences, DNA, healthcare

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