Up at 5AM: The 5AM Solutions Blog

The Business of Developing Tests for Diagnostics

Posted on Thu, Oct 02, 2014 @ 03:00 PM

As we’ve seen in previous posts, the world of diagnostic test development is quite complicated. In addition to the multiple ways a diagnostic test can get to market, there are many different types of organizations that develop and run tests. Take a look at this zoomed-in view of the Map of Biomedicine:

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Tags: personalized medicine, map of biomedicine, diagnostics

3 Personalized Medicine Barriers that We Can Knock Down Today

Posted on Thu, Sep 11, 2014 @ 03:00 PM

 According to the Personalized Medicine Coalition (PMC), personalized medicine is "... the tailoring of medical treatment to the individual characteristics of each patient…to classify individuals into subpopulations that differ in their susceptibility to a particular disease or their response to a specific treatment..." [emphasis ours]. It's an exciting proposition that could -- in the long run -- reduce health care costs overall, and offer individuals the best available treatments for them as people instead of the best available treaments for a disease.

So what's stopping us? There are lots of reasons that a personalized approach to medicine isn't yet part of the mainstream, but here is a roundup of 3 things standing between you and customized medical treatments.

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Tags: family health history, personalized medicine

Curing Cancer from the Inside Out

Posted on Thu, Aug 07, 2014 @ 12:00 PM

Over the past year, The Atlantic magazine has published several articles on curing cancer. Overall, the tone in each article is hopeful, but balanced.

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Tags: cancer, personalized medicine, diagnostics, Cure

Skin Cancer - Tales from Two Hemispheres

Posted on Tue, Jul 29, 2014 @ 03:38 PM

Experts around the globe agree that most skin cancers are preventable. They disagree, however, on what skin cancer prevention looks like.

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Tags: cancer, personalized medicine

Gaining Momentum: Patients as Healthcare Partners

Posted on Thu, Jun 26, 2014 @ 09:39 AM

It’s been a busy June. The air is thick with buzz about healthcare data, information and engagement from both the business and consumer sides of the healthcare coin. During the first month of summer 5AM and our partners and customers saw, heard, read , and -- in some cases -- ushered in signs of momentum toward patient-centered care. Here’s our short list:

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Tags: personalized medicine, data, OpenFDA

The Patient-Centered Future: Are We There Yet?

Posted on Tue, Jun 17, 2014 @ 06:48 AM

DIA kicked off its 50th Annual Meeting in San Diego, yesterday, where the theme is "Celebrate the Past - Invent the Future." The future (or part of it, anyway) seems to have arrived at DIA 2014 where, from keynote to closing, patient advocates have a prominent seat at the head of the table; a table previously reserved for health care professionals. It makes us hopeful: is the personalized, patient-centered future here?

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Tags: cancer, clinical trials, personalized medicine, cancer studies

5 Ways HHS is Bringing (Big Data) Power to the People

Posted on Tue, Jun 03, 2014 @ 11:44 AM

Yesterday, at Health Datapalooza, United States CTO, Todd Park, announced that the U.S. Department of Health and Human Services (HHS) and the Centers for Medicare & Medicaid Services (CMS) had launched initiatives that make tons of much-requested — but hard to get — health data accessible to the public. 

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Tags: health IT, clinical trials, personalized medicine, Big Data, Data Science, FDA

Next Generation Sequencing Applications, Challenges & Opportunities

Posted on Thu, Feb 13, 2014 @ 05:05 PM

Physicians currently rely on a variety of techniques to diagnose disease, from imaging to physical examinations to laboratory tests. Personalized medicine, which allows targeted therapies to be confidently prescribed, i.e. getting the right medication to the right patient at the right time, relies on a diagnosis that takes into account the molecular characteristics of the patient and the disease.

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Tags: NGS Sequencing, Companion Diagnostics, personalized medicine

5 Lessons Learned on Developing the Future of Personalized Medicine

Posted on Tue, Dec 10, 2013 @ 06:00 AM

The future of optimal health and cost effective, efficient care is dependent on the development of personalized medicine. Historically, scientific discovery and delivery of care has been developed from a one dimensional view of patients that assumed all individuals with a disease are the same – a one size fits all diagnosis and treatment regime which, over the past several decades, has failed to produce superior therapies and health outcomes.

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Tags: biobanking, personalized medicine, Big Data

Kalydeco Zydeco: Research Efforts Need Harmony

Posted on Thu, Feb 09, 2012 @ 06:00 AM

Zydeco is defined by the integration of far afield music genres, purportedly taken from a french saying “I’m so poor, I can’t afford any salt meat for the beans." The news of FDA’s approval of Kalydeco on February 1, 2012 illustrates the conundrum of where we are in the decades long march towards personalized medicine. There is much to celebrate. It’s music to the ears of many that the we are now beginning to attack the root cause cystic fibrosis rather than the symptoms. And more importantly for all the other diseases with genetic causes, we’ve been able to actually design a drug that fixes a genetic defect. But there isn’t a ton of pork that would make our biomedical ecosystem beans taste great.

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Tags: FDA, personalized medicine, FDA approval, Kalydeco, Cystic Fibrosis

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