Up at 5AM: The 5AM Solutions Blog

Wishing You Happy Holidays and a Happy New Year

Posted on Thu, Dec 26, 2013 @ 02:30 PM


A message of gratitude from 5AM Solutions' CEO, Brent Gendleman.

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The Power of Coincidence and How it Can Lead Us Astray

Posted on Tue, Dec 24, 2013 @ 06:00 AM

Katie Couric did a segment on her talk show on December 4th about the human papilloma virus (HPV) vaccine. The promo for that show had one graphic that said ‘HPV Vaccine Controversy’ and another that said ‘Potentially Dangerous’. I’ll leave the broader critiques to others (see Matthew Herper and Seth Mnookin for two good ones). Couric’s show was a biased view of the HPV vaccine that hysterically exaggerated the vaccine’s risks and gave very little time to more reasoned and balanced viewpoints.


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Tags: Vaccine

Where Continuous Learning and Innovation are Encouraged

Posted on Sun, Dec 22, 2013 @ 06:00 AM

I’ve been at 5AM Solutions for two and a half years now and I have loved every minute of it so far.  I get to work with great people who are excellent at what they do.  My resume doubled in length within the first year working here due to the fact that I work incredibly with smart people and a workplace culture that encourages continuous learning and innovation.  I learn something new here every day working here. 


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Tags: Life at 5AM

Happy Holidays from 5AM Solutions

Posted on Fri, Dec 20, 2013 @ 04:46 PM

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Tags: Happy Holidays

23andMe Hit By The FDA - But Their Real Challenge Is Biology

Posted on Thu, Dec 19, 2013 @ 06:00 AM

No doubt anyone with an interest in personal genomics has heard about 23andMe’s recent run-in with the Food and Drug Administration. The FDA has told them to stop marketing their Personal Genome Service because they didn’t have FDA approval for a diagnostic test. 23andMe has complied and now will only report ancestry and genealogy results to new customers.

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Tags: 23andMe

Running the Obstacle Course of Consent

Posted on Tue, Dec 17, 2013 @ 06:00 AM

After working as a data scientist in melanoma research for 6 years, I’ve come to appreciate the need for biobanking specimens, especially when studying rare diseases. The team I worked with at Yale would have never been able to collect the 150 specimens and blood samples needed to produce a large scale melanoma exome resequencing study without a concerted effort from physicians, patients, and biobankers to gather enough samples.

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Tags: biobanking, consent

An Insiders View of the Environment Where World Impacting Software is Developed

Posted on Sun, Dec 15, 2013 @ 06:00 AM

At 5AM Solutions, we make positive impacts in our clients’ software, and our clients’ software makes positive impacts on the world. As a 5AMer, I have developed software helping to power massively parallel targeted sequencing, variant analysis for research and clinical diagnostics, and bleeding edge assays for biotech startups. We tangibly move the state-of-the-art in the life sciences industry forward.

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Tags: Life at 5AM

A Review of Color in UX Design - 4 Tips on Designing a Color Palette

Posted on Thu, Dec 12, 2013 @ 06:00 AM

In our first two blog posts on color in UX design, Color Limitations and Color and Emotions we looked at some interesting facts about color and some of the context around their meaning. Part three brings these ideas together and provides tips for choosing color palettes for you designs and graphics.

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Tags: UX, Color

5 Lessons Learned on Developing the Future of Personalized Medicine

Posted on Tue, Dec 10, 2013 @ 06:00 AM

The future of optimal health and cost effective, efficient care is dependent on the development of personalized medicine. Historically, scientific discovery and delivery of care has been developed from a one dimensional view of patients that assumed all individuals with a disease are the same – a one size fits all diagnosis and treatment regime which, over the past several decades, has failed to produce superior therapies and health outcomes.

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Tags: biobanking, personalized medicine, Big Data

When Quality and Effective Communication are Baked Into the Process

Posted on Sun, Dec 08, 2013 @ 06:00 AM

I consider myself somewhat unique at 5AM in that I work remotely and I'm quality assurance focused. Being involved in this domain I enjoy knowing that I'm making a difference in lives through something I love doing. I also enjoy working at 5AM because we have a culture of quality. Our process and the people that make the process work are focused on improvement. 

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Tags: Life at 5AM

Extreme Visualization Makeovers - Genome.gov’s Published Genome Wide Associations Chart

Posted on Thu, Dec 05, 2013 @ 05:00 AM

This is a revisted article that is as relevant today as it was four years ago. Welcome to  Extreme Visualization Makeovers! In each installment, we’ll look at a different data visualization, chart, or graphic from the literature or the Web, and see if we can find ways to make it more effective. While each installment may not prove to be “extreme” – that makes a better title for our series, so we’re sticking with it.
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Tags: UX, Data Visualization

6 Points Along the Ontology Spectrum

Posted on Tue, Dec 03, 2013 @ 06:00 AM

This is the first post in our data modeling series. Today we give a broad perspective for different ways to represent knowledge and data. Some of our posts have talked about ontologies, controlled vocabularies, data models, and other kinds of knowledge representation. All of these share some commonalities, and exist along the Ontology (or sometimes Semantic) Spectrum.

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Tags: biobanking, semantics, ontology

A Toast to Making Kindness Contagious

Posted on Sun, Dec 01, 2013 @ 06:00 AM

Work is a vital and vibrant part of my life. 5AM's success is my two word job description. It has been for over 10 years no matter my role. At the core of 5AM are the people who did chose, do choose, and will choose to work here.

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Tags: Life at 5AM


Diagnostic Tests on the Map of Biomedicine


Download the ebook based on our popular blog series. This free, 50+ page edition features updated, expanded posts and redesigned, easier-to-read maps. 

FREE Biobanking Ebook

Biobanking Free Ebook
Get this 29 page PDF document on how data science can be used to advance biorepositories.

 Free NGS Whitepaper

NGS White Paper for Molecular Diagnostics

Learn about the applications, opportunities and challenges in this updated free white paper. 

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