Up at 5AM: The 5AM Solutions Blog

Ebola: New Outbreaks Amid New Hope for Vaccines

Posted on Fri, Mar 27, 2015 @ 03:00 PM

Liberia was poised to be the first of the three hardest-hit countries stricken with the Ebola epidemic to declare ebola_virus_virionitself free from the deadly virus that has ravaged the region for a year. The West African nation had gone two weeks without a new infection; and then a 44-year-old street vendor developed a fever. Her teenaged daughter, who'd tended to her sick mother developed a telltale headache.

To date, there have been nearly 25,000 Ebola cases in West Africa, and the disease has claimed more than 10,000 lives. Despite these (and other) recent setbacks, transmission rates have slowed, and yesterday, Reuters reported promising headway in the effort to find an effective vaccine. 

Currently, 600 people are enrolled in a National Institute of Allergy and Infectious Disease (NIAID)-sponsored clinical trials of two vaccine candidates, one from GlaxoSmithKline and the other from NewLink Genetics Corp. No one participating in the trials has been intentionally exposed to the virus to determine the vaccines' efficacy. Instead, researchers are looking at participants' immune responses to gauge whether the drugs work. 

Yesterday, NIH declared that both medicines appear to be safe, which means that they will progress to the next phase of efficacy testing. The two companies hope to enroll a total of 1500 trial participants and they continue to monitor results for a year.

You can read more Up at 5AM posts about Ebola here

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Tags: clinical trials, vaccines, ebola


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