Zydeco is defined by the integration of far afield music genres, purportedly taken from a french saying “I’m so poor, I can’t afford any salt meat for the beans." The news of FDA’s approval of Kalydeco on February 1, 2012 illustrates the conundrum of where we are in the decades long march towards personalized medicine. There is much to celebrate. It’s music to the ears of many that the we are now beginning to attack the root cause cystic fibrosis rather than the symptoms. And more importantly for all the other diseases with genetic causes, we’ve been able to actually design a drug that fixes a genetic defect. But there isn’t a ton of pork that would make our biomedical ecosystem beans taste great.